Good Quality Cromolyn Sodium CAS 15826 -37-6 Raw Powder 99% Sodium Cromoglycate

Model NO.
py0145
Standard
Bp2000
CAS
15826-37-6
Transport Package
25kg/Drum
Specification
99%
Trademark
puya
Origin
China
Production Capacity
10ton/Year
Reference Price
$ 180.00 - 270.00
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Product Description

Cromolyn Sodium CAS 15826-37-6 Raw Powder 99% Sodium Cromoglycate
Product Name
   Sodium cromoglicate
Appearance
White or White crystalline powder
Test method
HPLC
CAS
  15826-37-6
Specification
99%
Storage
Keep in cool & dry place, stay away from strong light and heat
Shelf Life
24 months

Sodium cromoglicate, also known as disodium cromoglicate, has a good preventive and therapeutic effect on immediate allergic reactions. Its mechanism of action is to stabilize the cell membrane of mast cells, prevent mast cells from degranulation, thereby inhibiting the release of allergic reaction mediators such as histamine, serotonin, and slow-reacting substances, thereby inhibiting the adverse effects of allergic reaction mediators on tissues. Its effect of inhibiting the release of allergic reaction mediators may be by inhibiting intracellular cyclic phosphoryl glycoside phosphodiesterase, resulting in an increase in the concentration of intracellular cyclic phosphoryl glycosides (cAMP), preventing calcium ions from being transported into mast cells, thereby stabilizing hypertrophy The cell membrane prevents the release of allergic reaction mediators

Specification
Test Items Test Standard
Appearance White or off-white crystalline powder
Identification A,B should complies to the standard
Acidity of Alkalinity Should complies to the standard
Related substance ≤0.5%
Limit of Oxalaet ≤0.35%
Heavy metals ≤20 ppm
Water ≤10.0%
Residual solvents Ethanol≤0.5%
Assay 98.0%~101.0%

Function

1.Sensitive mast cell membrane outside of the calcium channel, preventing calcium influx, inhibition of mast cell degranulation, reducing the release of histamine, slow reactant, leukotrienes and other inflammatory mediators, the role ofspecies selectivity and organ most sensitive to human lung mast cells.
2.Inhibition of sensory nerve endings to release substance P, neurokinin A and B induced tracheal smooth muscle spasm and mucosal edema.
3.Reducing the sensitivity of people with asthma for non-specific stimuli, reducing the attack of bronchospasm.


Application
Cromolyn sodium has been used to treat for asthma for many years. It is a derivative of khellin and is proved to be a unique antiallergic agent. The prior administration of cromolyn sodium inhibits allergen-induced histamine release in the animal experiments. Because the oral absorption of cromolyn sodium is minimal and only the powder form of it is available, cromolyn sodium is usually used through being inhaled from a special apparatus. Cromolyn sodium can suppress both immediate and late-onset asthmatic responses and suppress the release of NCF-A. It also inhibits the impairment of mucociliary transport induced by specific bronchial challenge. Moreover, cromolyn sodium also ameliorates exercise-induced asthma .

 

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GOUV.NE, 2023