Huayi Yiyao Factory Wholesale New Chemical Raw Material CAS 1379686-29-9 Sr9011 BMK Pmk
Model NO.
1379686-29-9
Sample
Avaiable
Transport Package
Various Packaging/According to Your Request
Specification
99%
Trademark
huayiyiyao
Origin
China
Production Capacity
5000kg/Year
Reference Price
$ 54.00 - 72.00
Description
Product Description
Product Description
Huayi Pharmaceutical Nanjing Co., Ltd. is a high-tech enterprise mainly engaged in the research and development and sales of high-quality drugs, agricultural chemicals, pharmaceutical intermediates and other related products. In terms of analysis and testing equipment, our company has an advanced and complete supporting system, forming an advanced chemical synthesis can quickly meet the personalized and serialized requirements for industrial production.
Our team by senior industry background and rich market experience of doctor, master and other professionals, committed to the relevant enterprises and institutions and research institutions at home and abroad to provide high-quality chemical products, can not only meet such customers special requirements for products, packaging and purity, and can satisfy the test in manufacturing from the mass production at various stages of comprehensive requirements.
SR9011 Biological Activity
| Description | SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. | ||||||||||||
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| Related Catalog |
Signaling Pathways
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Autophagy
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Autophagy
Research Areas
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Cancer
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| Target |
IC50: 790 nM (Rev-ErbBα), 560 nM (Rev-ErbBβ)[1] |
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| In Vitro | SR9011 dose-dependently increases the REV-ERB-dependent repressor activity assessed in HEK293 cells expressing a chimeric Gal4 DNA Binding Domain (DBD) - REV-ERB ligand binding domain (LBD) α or β and a Gal4-responsive luciferase reporter (REV-ERBα IC50=790 nM, REV-ERBβ IC50=560 nM). SR9011 potently and efficaciously suppresses transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9011 IC50=620 nM). SR9011 suppresses the expression ofBMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner[1] SR9011 suppresses proliferation of the breast cancer cell lines regardless of their ER or HER2 status. SR9011 appears to pause the cell cycle of the breast cancer cells prior to M phase. Cyclin A (CCNA2) is identified as a direct target gene of REV-ERB suggesting that suppression of expression of this cyclin by SR9011 may mediate the cell cycle arrest. Treatment with SR9011 results in an increase in cells in the G0/G1 phase and a decrease of cells in S and G2/M phase suggesting that activation of REV-ERB may be resulting in decreased transition from G1 to S phase and/or from S to G2/M phase[2]. | ||||||||||||
| In Vivo | SR9011 displays reasonable plasma exposure, thus, the expression of REV-ERB responsive genes is examined in the liver of mice treated with various doses of SR9011 for 6-days. The plasminogen activator inhibitor type 1 gene (Serpine1) is a REV-ERB target gene and displays dose-dependent suppression of expression in response to SR9011. The cholesterol 7α-hydroxylase (Cyp7a1) and sterol response element binding protein (Srepf1) genes have also been shown to be responsive to REV-ERB and are dose-dependently suppressed with increasing amounts of SR9011. After 12 days in D:D conditions mice are injected with a single dose of SR9011 or vehicle at CT6 (peak expression of Rev-erbα). Vehicle injection causes no disruption in circadian locomotor activity. However, administration of a single dose of SR9011 results in loss of locomotor activity during the subject dark phase. Normal activity returns the next circadian cycle, consistent with clearance of the drugs in less than 24h. The SR9011-dependent decrease in wheel running behavior in the mice under constant darkness conditions is dose-dependent and that the potency (ED50=56 mg/kg) is similar to the potency of SR9011-mediated suppression of a REV-ERB responsive gene, Srebf1 , in vivo (ED50=67mg/kg)[1]. | ||||||||||||
| Solvent |
In Vitro:
DMSO : ≥ 43 mg/mL (89.76 mM) * "≥" means soluble, but saturation unknown. |
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| Solubility |
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| Cell Assay | MCF10A, MDA-MB-231, MCF-7, MDA-MB-361, SKBR3, BT474 cells are plated in 6-well plates one day before treatment. The MTT cell proliferation assays are performed. Briefly, 3×103 to 5 × 103 cells per well are plated in 96-well plates. Twenty-four hours later, cells are treated with SR9011 (0, 2, 4, 6, 8 and 10 μM) or DMSO. Seventy-two hours after treatment, the cells are labeled with 1.2 mM MTT and incubated for 4 hours. DMSO is then added and readings are taken on a plate reader at 540 nm[2]. | ||||||||||||
| Animal Admin | Mice[1] For circadian gene expression experiments male C57BL6 mice (8-10 weeks of age) are either maintained on a L:D (12h:12h) cycle or on constant darkness. At circadian time (CT) 0 animals are administered a single dose of 100 mg/kg SR9011 (i.p.) and groups of animals (n=6) are sacrificed at CT0, CT6, CT12 and CT18. Gene expression is determined by real time QPCR. | ||||||||||||
| Storage |
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| Shipping | Room temperature in continental US; may vary elsewhere | ||||||||||||
| SMILES | O=C(N1CC(CN(CC2=CC=C(Cl)C=C2)CC3=CC=C([N+]([O-])=O)S3)CC1)NCCCCC |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 642.8±50.0 °C at 760 mmHg |
| Molecular Formula | C 23 H 31 ClN 4 O 3 S |
| Molecular Weight | 479.035 |
| Flash Point | 342.6±30.1 °C |
| Exact Mass | 478.180542 |
| LogP | 5.74 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.595 |
Huayi Pharmaceutical Nanjing Co., Ltd. is a high-tech enterprise mainly engaged in the research and development and sales of high-quality drugs, agricultural chemicals, pharmaceutical intermediates and other related products. In terms of analysis and testing equipment, our company has an advanced and complete supporting system, forming an advanced chemical synthesis can quickly meet the personalized and serialized requirements for industrial production.
Our team by senior industry background and rich market experience of doctor, master and other professionals, committed to the relevant enterprises and institutions and research institutions at home and abroad to provide high-quality chemical products, can not only meet such customers special requirements for products, packaging and purity, and can satisfy the test in manufacturing from the mass production at various stages of comprehensive requirements.
Our adhering to the "scientific development, green development, innovation and development" concept of development, customer success as own duty, makes every effort to to offer the best products, quality service to our customers.
Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force.
Our Main Products
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| 1-BOC-4-(4-BROMO-PHENYLAMINO)-PIPERIDINE | 443998-65-0 | White powder |
| 1-Phenyl-2-nitropropene | 705-60-2 | Yellow diamond crystal |
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| 4'-Methylpropiophenone | 5337-93-9 | Clear liquid or Yellow liquid |
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| Dimethyl terephthalate | 120-61-6 | Colorless rhombic crystal system crystal |
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| L(+)-Tartaric acid | 87-69-4 | White powder |
| DL-Tartaric acid | 133-37-9 | White powder |
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| 2-bromo-1-phenylhexan-1-one | 59774-06-0 | Yellow liquid |
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| hexanophenone | 942-92-7 | White liquid |
| 2-(2-chlorophenyl)cyclohexan-1-one | 91393-49-6 | Yellow liquid |
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| Cesium chloride (Caesium chloride) | 7647-17-8 | White powder |
1. What are your prices?
Our prices are subject to change depending on supply and other market factors. We will send you an updated price list after your company contact us for further information.
2. Do you have a minimum order quantity?
Yes, we require all international orders to have an ongoing minimum order quantity. If you are looking to resell but in much smaller quantities, we recommend you check with us on line.
3. Do you guarantee safe and secure delivery of products?
Yes, we always use high quality export packaging. We also use specialized hazard packing for dangerous goods and validated cold storage shippers for temperature sensitive items. Specialist packaging and non-standard packing requirements may incur an additional charge.
4. How about the shipping fees?
The shipping cost depends on the way you choose to get the goods. Express is normally the most quickest but also most expensive way. By seafreight is the best solution for big amounts. Exactly freight rates we can only give you if we know the details of amount, weight and way. Please contact us for further information.
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