99.9% USP Bp Eplerenone CAS 107724-20-9
Product Description
Product Name: Eplerenone
Chemical Name: Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-
lactone methyl ester
Molecular Formula: C24H30O6
Molecular weight: 414.49
CAS NO.: 107724-20-9
Appearance: white crystalline powder; slightly soluble in water.
Standard: Enterprise Standard
Product Parameters
TEST ITEMS
|
SPECIFICATION
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RESULTS
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Description
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White or Almost White Crystalline Powder
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white powder
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Identification
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A.B.
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Positive
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Assay
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97.0~102.0%
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99.3%
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Specific Rotation
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+101°~+105°
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+102.6°
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Loss On Drying
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1.0%max
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0.27%
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Melting Point
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153~157°C
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153.0~155.0°C
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Organic Volatile Impurities
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meets the requirement.
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Conforms
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Related Substances
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meets the requirement.
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Conforms
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Residual Solvents
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meets the requirement.
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Conforms
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Particle Size
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100% ≤ 20 microns
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Conforms
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Conclusion
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The specification conform with USP30 standard
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Eplerenone is an aldosterone antagonist used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spir onolactone, though it is much more selective for the mineralocorticoid receptor in comparison (i.e., does not possess any antiandrogen, progestogen, or estrogenic effects), and is specifically marketed for reducing cardiovascular risk in patients following myocardial infarction. It was marketed by Pfizer under the trade name Inspra but is now only available as a generic in every country except the United Kingdom. Eplerenone is a potassium-sparing diuretic, meaning that it helps the body get rid of water but still keep potassium.
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