Metronidazole
is used in the treatment of intestinal and parenteral amoeba disease (such as amoeba liver abscess, pleural amoeba disease, etc.).Also can be used to treat vaginal trichomoniasis, bagworm disease and cutaneous leishmaniasis, guinea worm infection.It is also widely used in the treatment of anaerobe infection.
Test Specification : BP2011/EP7.0 S pecification | ||
Test Items | Acceptance criteria | Test ed Results |
Appearance | Yellowish crystalline powder | Yellowish crystalline powder |
Solubility | Slightly soluble in water, acetone, alcohol, methylene chloride. | Conforms |
Identification | ||
Melting point(ºC) | 159~163 | 160. 2 ~160 .4 |
UV |
The solution shows an absorption maximum at 277nm, and a min
imum at 240. The specific absorption at the maximum is 365 to 395. |
Maximum absorption at
277
nm
Minimum absorption at 240nm Specific absorption is 381 |
IR | The sample spectrum complies with that of the reference standard spectrum. | Conforms |
Reaction of primary aromatic amines | The sample solution gives the reaction of primary aromatic amines. | Conforms |
Appearance of solution | T he solution is not more opalescent than reference suspensions II. | Conforms |
The solution is not more intensely coloured than reference solution GY6. | Conforms | |
Related Substances (HPLC) | ||
Any other unknown im purit y, % | ≤ 0. 05 | 0.02 |
Total Impurities , % | ≤0.2 | 0.04 |
Heavy metals(ppm) | ≤20 | Conforms |
Loss on drying(%) | ≤0.5 | 0.1 |
Sulphated ash(%) | ≤0.1 | 0.05 |
Assay (calculated on the dried substance ) ,% | 99.0~101.0 | 99.8 |
Note: N.D indicates " Not detected " |