5-Bromoindole Chemical Properties |
Melting point | 90-92 °C (lit.) |
Boiling point | 228.5°C (rough estimate) |
density | 1.5466 (rough estimate) |
refractive index | 1.6550 (estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | 126mg/l (calculated) |
pka | 16.04±0.30(Predicted) |
form | Powder or Chunks |
color | White to light brown |
BRN | 112877 |
InChIKey | VXWVFZFZYXOBTA-UHFFFAOYSA-N |
CAS DataBase Reference | 10075-50-0(CAS DataBase Reference) |
EPA Substance Registry System | 1H-Indole, 5-bromo- (10075-50-0) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36-24/25-37/39 |
WGK Germany | 3 |
Hazard Note | Irritant |
HS Code | 29339990 |
5-Bromoindole Usage And Synthesis |
Chemical Properties | white to light brown powder or chunks |
Uses | A potential inhibitor of GSK-3 |
Purification Methods | Purify it by steam distillation from a faintly alkaline solution. Cool the aqueous distillate, collect the solid, dry it in a vacuum desiccator over P2O5 and recrystallise it from aqueous EtOH (35% EtOH) or pet ether/Et2O. UV in MeOH has at 279, 287 and 296nm (log 3.70, 3.69 and 3.53). The picrate has m 137-138o(dec) (from max Et2O/pet ether). [UV: Thesing et al. Chem Ber 95 2205 1962, UV and NMR: Lallemand & Bernath Bull Soc Chim Fr 4091 1970, Beilstein 20/7 V 36.] |
5-Bromoindole Preparation Products And Raw materials |
Preparation Products | 1-METHYL-1H-INDOLE-5-BORONIC ACID 2,2-DIMETHYL PR OPANE DIOL-1,3-CYCLIC ESTER --> C-(1H-INDOL-5-YL)-METHYLAMINE --> 5-Indolylboronic acid --> 5-Cyanoindole --> 5-Acetylindole --> Indole-5-carboxaldehyde --> 5-Bromoisatoic anhydride --> (R)-5-BROMO-3-[(1-METHYL-2-PYRROLIDINYL)METHYL]-1H-INDOLE --> INDOLE-5-METHANOL --> 5-Bromo-1-(tert-butoxycarbonyl)-1H-indol-2-ylboronic acid --> 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-INDOLE --> 3-ACETOXY-5-BROMOINDOLE --> 5-Bromo-3-cyanoindole |