Product Information
Description |
FOXO3A rabbit polyclonal |
Protein full name |
Forkhead box protein O3 |
Synonyms |
FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O3 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse FOXO3A |
Isotype |
IgG |
Purity |
Affinity purification |
Predicted MW. |
72/97KDa |
Observed MW. |
72/97KDa |
Uniprot ID |
Q9WVH4,O43524 |
Applications
Applications |
WB |
Species |
Human, Rat, Mouse |
Dilution |
1:1000 |
Positive tissue |
293T, MCF7, liver cancer, glioma, lung, brain |
Images
|
Western blot analysis of FOXO3A (GB11092-1) at dilution of 1:1000. Lane 1: 293T cell lysate Lane 2: MCF7 cell lysate Lane 3: SH-SY5Y cell lysate Lane 4: Human liver cancer tissue lysate Lane 5: Human glioma tissue lysate Lane 6: Mouse lung tissue lysate Lane 7: Mouse brain tissue lysate Lane 8: Rat brain tissue lysate |
Background
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Storage
Storage |
Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer |
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |