Product Information
| Description |
FOXO3A rabbit polyclonal |
| Protein full name |
Forkhead box protein O3 |
|
Synonyms |
FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O3 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse FOXO3A |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
| Predicted MW. |
95KDa |
| Observed MW. |
95KDa |
|
Uniprot ID |
Q9WVH4 |
Applications
| Applications |
WB |
| Species |
Rat |
|
Dilution |
1:500-1:1000 |
| Positive tissue |
Heart, lung |
Images
|
|
Western blot analysis of FOXO3A (GB11092) at dilution of 1:750. Lane 1: Rat heart tissue lysate Lane 2: Rat lung tissue lysate |
Background
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Storage
|
Storage |
Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles. |
|
Storage Buffer |
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |